types of cancer

Malignant Mesothelioma


Mesothelioma is a cancer that occurs in the mesothelium. Mesothelium is a thin protective layer of tissue that covers the majority of the internal organs. Mesothelioma is an aggressive form of cancer which is difficult to treat. This form of cancer is further divided into:

  • Pleural Mesothelioma: This type of cancer happens to the tissue that surrounds the lungs (pleura) and is the most common form of mesothelioma. Three out of every four cases of mesothelioma disease begin in the pleural mesothelium
  • Other rarer forms of mesothelioma are peritoneal mesothelioma – which affect the tissue of the abdomen. Mesothelioma can also occur in the surrounding tissues of the heart and testicles.
  • Regardless of their origin, malignant cells from the mesothelium can invade and damage nearby tissues, they can also metastasize, or spread, to other parts of the body. Mesothelioma is often diagnosed when the disease is in the advanced stage. The five-year survival rate is around 5% to 10%.


    Signs and symptoms of mesothelioma vary depending on where the cancer occurs. Pleural mesothelioma, which affects the tissue that surrounds the lungs, causes signs and symptoms that may include:

  • Shortness of breath. Accumulation of fluid in the pleura caused by the mesothelioma, if sufficiently large, may also contribute to the shortness of breath
  • Chest pain.
  • Painful coughing
  • Unusual lumps of tissue under the skin of the chest
  • Unexplained weight loss.
  • Peritoneal mesothelioma, which occurs in tissue in the abdomen, causes signs and symptoms that may include:
  • Abdominal swelling and pain
  • Nausea
  • Unexplained weight loss
  • Symptoms of other types of mesothelioma are unclear, since these forms of the disease are very rare. Pericardial mesothelioma, which affects tissue that surrounds the heart, has symptoms such as breathing difficulty and chest pains. Mesothelioma of tunica vaginalis, which affects tissue surrounding the testicles, may be first detected as swelling or a mass on a testicle.


    he main risk factor for mesothelioma is exposure to asbestos. Asbestos is a group of minerals with thin microscopic fibers. These fibers are resistant to heat, fire, and chemicals and do not conduct electricity. Due to these properties, asbestos has been mined and used extensively in the construction, automotive, and other industries. Asbestos fibers particulates are released into the air, when used in the manufacturing industries. They can then be easily inhaled or swallowed, leading to serious health problems. Approximately 75% of mesothelioma cases can be linked to exposure to asbestos. Other risk factors of mesothelioma are:

  • Exposure to zeolites: These minerals are chemically related to asbestos and is believed to be a cause factor of mesothelioma.
  • Radiation: There have been a few published reports of mesotheliomas that developed following exposure to high doses of radiation to the chest or abdomen.
  • SV40 virus: Some studies in laboratory animals have raised the possibility that infection with the simian virus 40 (SV40) might increase the risk of developing mesothelioma.
  • Diagnosis

    If there are symptoms that might indicate mesothelioma, the doctor will conduct a physical exam to check for any lumps or other unusual signs. The doctor may order imaging scans, such as a chest X-ray or CT scan of your chest or abdomen, to look for abnormalities. Depending on the findings, further tests may be recommended to determine whether mesothelioma or another disease is causing the symptoms.

  • Blood Tests: Blood levels of 3 substances – fibulib 3, osteopontin and soluble mesothelin related peptides (SMRPs) are often seen to be elevated in people suffering from mesothelioma.
  • Fluid and Tissue Sample tests: Build-up of fluid in the body that may be related to mesothelioma, therefore the doctor can remove a sample of the fluid by inserting a needle through the skin into the area of fluid build-up. The fluid can then be examined under a microscope for cancer cells
  • Biopsy: It is a procedure through which a small portion of the affected tissue is removed and sent for laboratory examination. It is the only way to accurately determine whether there is mesothelioma. Depending on the area of the body that is affected, the doctor selects the right biopsy procedure:
    • Inserting a needle through the skin. The doctor might remove fluid or a piece of tissue with a thin needle inserted through the skin on your chest or abdomen.
    • Collecting a sample of tissue during surgery. A fluid or tissue sample might be collected during an operation. The surgeon might make a small incision and insert a tube with a video camera to see inside your chest or abdomen. Special tools can be passed through the tube to collect a tissue sample.
  • Once the mesothelioma is confirmed, additional tests maybe recommended to understand whether the cancer has spread to the lymph nodes or to other areas of the body. The tests may include:
  • CT scans of the chest and abdomen
  • MRI
  • PET-CT
  • Basis the tests, the stage of the cancer can be determined and the optimal treatment can be planned.


    Treatment for mesothelioma depends on a number of factors such as (but not limited to) stage of the cancer, size of the mesothelioma, whether it can be removed completely by surgery or not, fluid build-up in the chest and/or abdomen, age and general health, type of mesothelioma cells and whether it is a recurrence or not. Three standard types of treatment are used: surgery, radiation, and chemotherapy. Treating mesothelioma often involves a combination of two or all three Surgery Surgery for malignant mesothelioma can be divided into two categories – those performed for the relief of symptoms and those performed with curative intent. Four main types of surgeries can be done to treat mesothelioma:

  • Wide local excision: This removes the cancer along with some of the healthy surrounding tissue
  • Pleurectomy and decortication: In this case a part of the pleura covering the lungs is removed along with a part of the chest lining, and outside surface of the lungs.
  • Extrapleural pneumonectomy: This involves removing one whole lung and part of the lining of the chest, the diaphragm, and lining of the sac around the heart.
  • Pleurodesis: This involves using chemical or drugs to make the lung lining scar and stick to the lung. The scarring stops the fluid build-up
  • Radiotherapy In radiotherapy, high-energy X-rays and other types of radiation is used to kill mesothelioma cells or prevent them from growing. Radiation may be administered externally or internally. While external radiation therapy uses machines outside the body to send radiation toward the cancer, internal radiation uses a radioactive substance sealed in needles, seeds, wires, or catheters that are placed directly into the area near the mesothelioma. Chemotherapy This is a cancer treatment that uses drugs to stop the growth of mesothelioma cells, either by killing the cells or by stopping them from dividing. Chemotherapy can be administered orally, injected into a vein or muscle to enter the bloodstream and reach mesothelioma cells throughout the body, or it can be placed directly into the affected area of the body to mainly affect mesothelioma cells in that area. Sometimes doctors use more than one chemotherapy drug. This is called combination chemotherapy.

    197 replies on “Malignant Mesothelioma”

    I have read your article carefully and I agree with you very much. This has provided a great help for my thesis writing, and I will seriously improve it. However, I don’t know much about a certain place. Can you help me?

    Thank you very much for sharing. Your article was very helpful for me to build a paper on After reading your article, I think the idea is very good and the creative techniques are also very innovative. However, I have some different opinions, and I will continue to follow your reply.

    Do you mind if I quote a couple of your articles as long asI provide credit and sources back to your website?My blog site is in the very same niche as yours and my users would certainly benefit from some of the information you present here.Please let me know if this okay with you. Thanks!

    I absolutely love your website.. Great colors & theme.
    Did you make this amazing site yourself? Please reply back as I’m attempting to create my very
    own website and would like to find out where you got this from or exactly what the theme is called.

    Appreciate it!

    I really love your site.. Pleasant colors & theme.
    Did you develop this website yourself? Please reply back as I’m attempting to create my own personal blog and would love to
    know where you got this from or just what the theme is named.
    Appreciate it!

    I’ve been browsing on-line more than three
    hours as of late, but I by no means found any interesting article
    like yours. It is pretty price enough for me. In my opinion, if all webmasters and bloggers made excellent content as you probably did,
    the net will be a lot more useful than ever before.

    Simply desire to say your article is as astounding. The clearness in your post is just nice
    and i could assume you are an expert on this subject. Fine with your permission allow
    me to grab your feed to keep up to date with forthcoming post.
    Thanks a million and please continue the enjoyable work.

    I am not sure where you are getting your info,
    but great topic. I needs to spend some time learning much more or understanding more.
    Thanks for excellent info I was looking for this information for my mission.

    Hi there, just became alert to your blog through Google, and found that it is truly
    informative. I’m going to watch out for brussels. I will be grateful if you
    continue this in future. A lot of people will be benefited from your writing.

    Link exchange is nothing else however it is only placing the other person’s website link on your page
    at proper place and other person will also do similar
    for you.

    We’re a group of volunteers and opening a new scheme in our community.
    Your web site provided us with valuable info to work on. You have done a formidable job
    and our entire community will be thankful to you.

    wonderful post, very informative. I’m wondering why the opposite experts of this sector don’t notice this.

    You should proceed your writing. I am sure, you’ve a huge readers’
    base already!

    First of all I would like to say awesome blog!
    I had a quick question in which I’d like to ask if you don’t mind.
    I was curious to know how you center yourself and clear your head before writing.
    I have had trouble clearing my thoughts in getting my ideas out.
    I truly do enjoy writing but it just seems like the first 10 to 15 minutes
    are lost just trying to figure out how to begin. Any ideas
    or hints? Cheers!

    Next time I read a blog, Hopefully it does not disappoint me just as much as this one. I mean, Yes, it was my choice to read, but I actually thought you would have something useful to say. All I hear is a bunch of complaining about something that you could fix if you weren’t too busy seeking attention.

    Howdy! I could have sworn I’ve visited this website before but after
    browsing through a few of the posts I realized it’s new to me.
    Anyways, I’m certainly happy I discovered it and I’ll be
    book-marking it and checking back often!

    Its such as you learn my mind! You seem to know a lot approximately this, such as you wrote the guide in it or something.
    I feel that you simply can do with some percent to force the message home a little
    bit, but instead of that, this is wonderful blog.

    A great read. I’ll certainly be back.

    I loved as much as you’ll receive carried out right here. The sketch is tasteful,
    your authored subject matter stylish. nonetheless, you command get got an impatience over that you wish be delivering the following.
    unwell unquestionably come further formerly again since
    exactly the same nearly very often inside case you
    shield this hike.

    Do you mind if I quote a few of your posts as long as I provide credit and sources back to
    your blog? My blog site is in the exact same niche as yours and
    my visitors would certainly benefit from a lot of the information you present here.
    Please let me know if this okay with you. Many thanks!

    It is perfect time to make a few plans for the long run and it is time to be happy.
    I’ve read this put up and if I may I wish to counsel you few interesting things or advice.
    Maybe you can write subsequent articles regarding
    this article. I want to read even more things about it!

    Hey there! I could have sworn I’ve been to this site before but after browsing
    through some of the post I realized it’s new
    to me. Anyways, I’m definitely glad I found it and I’ll be book-marking
    and checking back frequently!

    I’m amazed, I must say. Rarely do I come across a blog that’s equally educative
    and engaging, and let me tell you, you’ve hit the nail
    on the head. The problem is something that not
    enough people are speaking intelligently about.
    I am very happy that I found this during my search for
    something concerning this.

    Howdy vey cool site!! Man .. Beautiful .. Superb ..
    I’ll bookmark your site and take the feeds additionally?
    I am happy to seek out so many helpful info right here in the post, we need
    work out more strategies on this regard, thanks for sharing.
    . . . . .

    What’s Taking place i’m new to this, I stumbled upon this I have
    discovered It positively helpful and it has
    aided me out loads. I hope to give a contribution & assist other users like its
    aided me. Great job.

    Leave a Reply

    Your email address will not be published. Required fields are marked *